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In fact, J. 1215. The most striking observation, first made by Chambon, is that almost all introns in nu- clear mRNA precursors begin and end the same way: exonGUintronAGexon In other words, the first two bases in the intron of a tran- script are GU and the last two are AG. 20 -14,344 '5149K02 5S9E-04 1611 1626M -6464 54 28. Savings plan and in home. The normal role of the prion in the brain is not yet clear, but experiments in mice lacking the prion gene, and therefore unable to make the normal ver- sion of the protein, indicate that it may protect mammals against dementia Infectious Agents 279 (a) Duplication of DNA genome (b) Duplication of RNA genome Double- stranded DNA DNA polymerase Single- stranded RNA Single- stranded DNA Double- stranded DNA Reverse transcriptase DNA polymerase RNA polymerase Newly synthesized RNA Figure 11.

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