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4 V vs. Ratio these companies are aligned together. txt INDEX cardiotoxicity amphetamines, 402 antidepressants MAOIs, 171, 191 SNRIs, 176 TCAs, 169, 170, 186, 191, 427 cocaine, 4001 neuroleptics, 293 thioridazine enantiomers, 97 cardiovascular system and 5-HT, 143 see also cardiotoxicity catecholamines see dopamine; noradre- naline cellular structure, brain, 713, 16 psychoneuroimmunology, 435 see also neurons cerebellum, 2 dystonia, 455 cerebrospinal fluid, 7 cerebrum, 3 see also basal ganglia; cortex charas, 411 chelating agents, 67, 3656, 368 children see paediatric psychopharma- cology China white, 403 chiral structures, 956 chiral switching, 96 chloral hydrate, 251, 429 chlordiazepoxide, 212, 213, 241, 429 chlormethiazole, 251 chlorpromazine anxiety disorders, 236 conduct disorders, 420 drug interactions, 461 elderly people, 428 and functional neuroanatomy, 13 schizophrenia, 2556, 269, 284, 286 cholecystokinin, 218, 2234 choline uptake, 62, 63 cholinergic system see acetylcholine cholinergic system cholinomimetic drugs AD, 39, 40, 361, 3634, 368 mania, 197 receptor sequestration, 3940 cigarettes cannabis, 411, 412, 41516 drug interactions, 461 nicotine, 3989 505 circadian rhythm neurotransmitters, 1601, 2434 sleep, 2424 citalopram, 171, 172, 173 chemical structure, 173 elderly people, 427 enantiomers, 98, 175 side effects, 189 clinical trials, 101, 10411 confidence intervals, 1056 costs of treatment, 109 double-blind, 106 error types, 106 evaluation, 1056 informed consent, 1078 interim analyses, 108 limitations, 110 meta-analyses, 108 null hypotheses, 105 numbers of patients in, 108 open, 1067 placebos, 1078, 110 pre-clinical drug tests, 1014, 10910 prescribing decisions, 11011 purpose, 1045 statistical significance, 105, 106, 108 types, 1067 clobazam, 87, 303, 304, 305, 3089, 311 clomipramine children, 421, 423 OCD, 224, 225, 423 clonazepam, 303, 304, 305, 308 clonidine childhood tic disorders, 421 depression, 156 mania, 208 PTSD, 227 cloning, 1268 clozapine, 2701, 275 chemical structure, 274 drug interactions, 94 5-HT receptor activity, 49, 50, 146 in vitro receptor binding, 271 sigma receptors, 4556 cocaine abuse, 376, 3801, 399, 4002, 403 computed tomography, SPECT, 34 conduct disorders, 420 confidence intervals, 1056 contraceptive pill, 71 corpus callosum, 1, 3 710 Chapter 17 17.

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(2), cAMP-dependent protein kinase (PKA) phosphorylates serine residue 40. Large-scale production The need for a successful large-scale MAb production technique is indicated by the growing commercial market for antibody-based products and the increased importance of in vivo diagnostic as well as therapeutic applica- tions.

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